Abstract: Abstract: According to reliable data, the epidemic of poultry infectious diseases causes billions of economic losses every year in China. It not only seriously threatened the healthy development of the poultry industry, but also had a serious impact on the food security and human health. Compared with the developed countries, the problem of the poultry disease prevention in China is that farmers always ignore the importance of comprehensive management and control, and, tend to excessive reliance on vaccines and antibiotics for the infectious diseases. Experience has shown that without the daily management, only relying on antibiotics and vaccines can't effectively control the spread of infectious disease. This is because that although vaccines can improve the immunity of animal, they can't kill pathogenic microorganism which have already existed in animal and farm. At the same time, in the face of new infectious diseases due to continuous mutation of pathogenic microorganism, the development of a new novel vaccines always have a lag period. In this case, evaluation of the risk factors which can affect the spread of the disease will help to develop and to strengthen chicken farm management, resulting effective disease control measure. As for antibiotics, the problem of drug-resistant has produced serious influence on the treatment of related diseases. In addition, antibiotics in animal waste ended in environment also have been reported to cause problems in ecosystems and to human health. The purpose of this paper is to study the effect of meteorological factors on the prevalence of Avian pasteuretlosis by using a variety of statistical methods and mathematical model. Data for poultry infectious diseases between Jan., 2006 to Dec., 2016 were obtained from China National veterinary. Provincial meteorological data were obtained from China State Meteorological Administration. By using seasonal analysis, time series analysis method and the zero-inflated negative binomial model, trend analysis and evaluation model of Avian pasteuretlosis have been conducted. This study included: 1) By using seasonal analysis and time series analysis, we studied the epidemic tendency of Avian pasteuretlosis. From the results, we found that the Avian pasteuretlosis, which have been included in the "Official Veterinary Bulletin", was influenced by the seasonal factors and the number of disease cases. 2) By using Zero-inflated negative binomial model, disease data of Avian pasteuretlosis in months and the provincial level meteorological data in every month of the whole country during research period, we reviewed the relationship between meteorological factors and Avian pasteuretlosis cases. Results indicated that there was a high possibility of Avian pasteuretlosis when the weather conditions with high temperature and air humidity and low wind speed. In summary, we studied the epidemic trend of Avian pasteuretlosis and the effect of meteorological factors on this poultry disease. The study offered a reliable theory for setting up the early warning system of Avian pasteuretlosis, and it also provided a reference to the control of other poultry infectious diseases. In further research work, more risk factors, such as the economy, traffic and the migration of migratory birds, should be considered in the analysis to improve the accuracy of the model prediction.