Abstract: Agricultural mechanization urgently needs to be upgraded after the rapid high-quality development in recent years in China. A high-quality development of agricultural mechanization has become the key parts of modern agriculture. An evaluation indicator system can be beneficial to the identification of the current situation, and thereby to guide the high-quality development of agricultural mechanization. In this study, an indicator system was constructed to evaluate the high-quality development of regional agricultural mechanization in China, including five secondary indicators: the innovation-driven development, coordination and optimization, quality and efficiency, green and sustainability, as well as the benefit and contribution, and 26 tertiary indicators. Taking the typical counties of southern, central and northern Jiangsu as research areas, both subjective and objective empowerment methods were adopted for the weight determination, further to calculate the secondary indicators and comprehensive indicators in the evaluation indicator system. The results demonstrate that there was an overall unbalanced trend in the regional development of agricultural mechanization in the three counties. This indicator system was expected to evaluate the high-quality development of regional agricultural mechanization. The evaluation data can serve as the sound reference for the policy-making on the high-quality development of regional agricultural mechanization. Therefore, the high-quality development can be set as the guidance for the agricultural mechanization in all regions, where the problem-orientation can be used to enhance the specific areas of agricultural mechanization, providing the important support for the rural revitalization.