Abstract: The Karst region of Southwest China is a complex region with a fragile ecological environment and multi-dimensional poverty. Research on the spatial deprivation and spatial pattern of multi-dimensional poverty in this region is conducive to revealing the causes of poverty in specific regions, thus providing a theoretical basis for formulating poverty control measures. Based on introducing the concept of poverty spatial deprivation, this paper constructed the index system of poverty spatial deprivation, and studied the identification and spatial pattern of poverty spatial deprivation in 153 administrative villages in Luoping County, Yunnan Province by means of spatial autocorrelation, hot-spot analysis and geographical detector. The results show that Luoping County has a deep level of poverty spatial deprivation, as the dimensions of natural deprivation, economic deprivation, ecological deprivation, ability deprivation and opportunity deprivation and the spatial deprivation of multi-dimensional poverty are mainly in a medium-high degree deprivation. Among them, natural deprivation is mainly in a medium level of deprivation, while economic deprivation, ecological deprivation, ability deprivation and opportunity deprivation are mainly in a high level of deprivation and the spatial deprivation of multi-dimensional poverty is mainly in a medium and high level of deprivation. Moreover, the spatial deprivation of multi-dimensional poverty has a strong degree of agglomeration with 6 high-value agglomeration areas at the county boundaries, 1 low-value agglomeration area at the county center, and 2 outlier areas at the urban-rural junction, thus the distribution of poverty spatial deprivation has a significant positive correlation.Besides, poverty spatial deprivation has a significant difference in the distribution of spatial pattern, as different dimensions of poverty spatial deprivation present different morphological characteristics: the spatial distribution index of the natural deprivation presents a core-peripheral structure, the spatial distribution index of the economic deprivation gradually increases outward at a 45° axis from the center of the city to the northwest of the city, the spatial distribution index of the ecological deprivation presents a double-core structure, the spatial distribution index of the opportunity deprivation presents a "lv (Chinese character)" structure, the spatial distribution index of the ability deprivation presents a structure of "one main and several subsidiaries" and the spatial distribution index of the multi-dimensional poverty spatial deprivation presents a structure of "low center and high periphery". In addition, among forces that determine the effect of uni-dimensional deprivation on multi-dimensional poverty spatial deprivation, opportunity deprivation has the strongest determining force, followed by ability deprivation and natural deprivation and ecological deprivation are relatively weak, and the interaction between any two single dimensions is greater than the effect of a single dimension, which indicates that there is a two-factor enhancement between two single dimensions. Finally, in conjunction with the 5 key identified areas of poverty spatial deprivation areas, different categories of policies and suggestions are proposed to provide scientific references for the study of the coordination between urban and rural poverty control and the implementation of the rural revitalization strategy.