Abstract: To improve the oil extraction rate of oil press, the three-dimensional model of press chamber was established by CATIA. The crushing simulation model of the press chamber of the domestic oil press was built by EDEM. Orthogonal experiment with multiple indices, three factors was used to explore the relationship between the work performance of squeezing peanuts in the press chamber of the household press. And the rotation speed of the press rod, dosage quantity and the screw pitch of the pressing rod. The range method was used to analyse the primary and secondary order of the influencing factors. Through matrix analysis, the fracture ratio of material particle bond fracture, the theoretical oil yield and the three-factor structure matrix were obtained. It included index layer matrix M, factor layer matrix T and horizontal level matrix S. The weight matrix of two index values were obtained then, and the weight of each factor level was calculated. According to the results, the influence of various factors on the overall working capacity of the press chamber optimal working scheme was determined by the primary and secondary order. The results showed that the primary and secondary subsequence of factors of material bond fracture ratio was: press rod speed > dosage quantity > press rod pitch. With the increase of the rate of press rod, the fracture ratio of the bond was larger. With the growth of screw pitch, it decreased first and then increased. With the growth of the amount of material, the quantity of material was decreasing. And for the evaluation index of the material bond fracture ratio, the optimal combination was A3B1C3. The order of influencing factors of theoretical oil yield could be seen as: press rod speed > dosage quantity > press rod pitch. With the growth of rotational speed, the theoretical oil yield increased gradually. With the growth of screw pitch, it decreased first and then increased. With the growth of the screw pitch of the press rod, it increased gradually. And for the evaluation index of general oil production rate, the optimal scheme was A3B1C2. Through matrix analysis, the order of the influence of each factor on the index value of the orthogonal test is A (press rod speed) > B (dosage quantity)>C (press rod pitch). The weight of factor A3, B1, C3 was the largest. Therefore, the best scheme for press chamber was A3B1C3. That was to say, the optimum working parameters of the press cavity of the press machine were as follows: the rotation speed of the press rod was 80 r/min, the dosage quantity was 300 grains per minute, 6.3 mm was obtained as the press rod. Verify by verification test, the oil yield of the nine groups were 42.67% and 41.25%, and 40.65% and 44.05%, and 41.83% and 42.05%, and 43.85% and 43.96%, 43.06% respectively. The oil yield of peanut was 45.20% under the optimum working parameters obtained by matrix analysis and it was higher than the other 9 clusters. The results above verified that the simulation results were reasonable.